AFAP1L2/XB130 (D4A5) Rabbit mAb

• 产品编号：CST-12796S      品牌：CST       原厂货号：12796S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

</p>AFAP1L2/XB130 (D4A5) Rabbit mAb可以识别内源性总的AFAP1L2/XB130蛋白。.</p>单克隆抗体由合成肽段免疫动物产生，该肽段与人AFAP1L2/XB130蛋白Val391附近氨基酸一致。</p>肌动蛋白丝相关蛋白（AFAP）家族包含有AFAP1，AFAP1L1和AFAP1L2/XB130，一组结构相似的蛋白在调控细胞骨架活性和信号转导过程中发挥了不同的作用。Actin filament-associated protein 1-like 2 (AFAP1L2, XB130)是一个调控多种疾病下游信号通路的接头蛋白，包括Src, Akt,和甲状腺特异性kinase RET/PTC（1-3）。通过这些信号通路，AFAP1L2/XB130介导了转录调控，细胞增殖，运动和microRNA表达（4,5）。研究显示AFAP1L2/XB130涉及了甲状腺肿瘤细胞的增殖和存活（6），还可能在胃癌预后过程中发挥作用（7）。

1. Xu, J. et al. (2007) J Biol Chem 282, 16401-12.
2. Shiozaki, A. et al. (2012) PLoS One 7, e43646.
3. Lodyga, M. et al. (2009) Oncogene 28, 937-49.
4. Lodyga, M. et al. (2010) J Cell Sci 123, 4156-69.
5. Takeshita, H. et al. (2013) PLoS One 8, e59057.
6. Shiozaki, A. et al. (2011) Am J Pathol 178, 391-401.
7. Shi, M. et al. (2012) PLoS One 7, e41660.

原厂资料：

Specificity / Sensitivity

<p>AFAP1L2/XB130 (D4A5) Rabbit mAb recognizes endogenous levels of total AFAP1L2/XB130 protein.

Source / Purification

<p>Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val391 of human AFAP1L2/XB130 protein.

Background

<p>The actin-filament associated protein (AFAP) family consists of AFAP1, AFAP1L1, and AFAP1L2/XB130, a group of structurally similar proteins that play distinct roles in the regulation of cytoskeletal dynamics and signal transduction. Actin filament-associated protein 1-like 2 (AFAP1L2, XB130) is an adaptor protein that regulates signaling downstream of multiple kinases, including Src, Akt, and the thyroid specific kinase RET/PTC (1-3). Through these pathways, AFAP1L2/XB130 mediates transcriptional regulation, cell proliferation, motility, and microRNA expression (4,5). Research has shown that AFAP1L2/XB130 is involved in the proliferation and survival of thyroid tumor cells (6), and may have value in gastric cancer prognosis (7).

1. Xu, J. et al. (2007) J Biol Chem 282, 16401-12.
2. Shiozaki, A. et al. (2012) PLoS One 7, e43646.
3. Lodyga, M. et al. (2009) Oncogene 28, 937-49.
4. Lodyga, M. et al. (2010) J Cell Sci 123, 4156-69.
5. Takeshita, H. et al. (2013) PLoS One 8, e59057.
6. Shiozaki, A. et al. (2011) Am J Pathol 178, 391-401.
7. Shi, M. et al. (2012) PLoS One 7, e41660.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.