Peroxisomes, ubiquitous organelles of eukaryotic cells, are involved in a number of metabolic processes. Their formation involves membrane generation, targeting and insertion of peroxisomal membrane proteins (PMPs) into the membrane, and transport of matrix proteins across the newly formed membrane. Peroxiredoxins are a family of peroxisomal proteins that includes peroxiredoxin I, II, III, IV, and V. These proteins are homologous to thioredoxin peroxidase, and have been implicated in the reduction of H2O2 levels. Peroxiredoxin V (aka AOEB166/PMP20) is a widely expressed peroxisome matrix protein that contains a C-terminal peroxisomal targeting signal 1 that facilitates binding to the PTS1 receptor, PEX5. Peroxiredoxin V is localized to the cytoplasm and peroxisomes, and displays thiol-specific antioxidant activity in vitro . In rat lung, acute inflammation induced by LPS is associated with an increase in Peroxiredoxin V mRNA levels. Other peroxiredoxins have been shown to reduce the amount of H2O2-induced apoptosis when overexpressed. Similarly, overexpression of Peroxiredoxin V inhibits p53-induced apoptosis. Thus, peroxiredoxin V may be an important anti-apoptotic enzyme found in peroxisomes.
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注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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