1.This reagent has been pre-diluted for use at the
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描述:
The monoclonal antibody RB1 recognizes both 15- and 9kD forms of human granulysin, a protein present in granules of human natural killer (NK) cells and activated cytotoxix T lymphocytes (CTLs). It is cytolytic against both tumor and microbial targets and has been found to kill extracellular and intracellular mycobacterium tuberculosis through a granule-dependent mechanism. Granulysin is a member of a larger family of proteins known as saposin-like proteins (SAPLIP) that are thought to associate with lipids. The crystal structure of granulysin suggests that it functions as a lytic molecule. To date, no granulysin homolog has been found in mice, precluding the generation of granulysin knockout animals.
原厂资料:
注意事项:
1.This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 × 10^6 cells in a 100-μl experimental
sample (a test).
2.Since applications vary, each investigator should titrate the reagent to obtain optimal results..
3.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
4.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.