The clone 105HB29 recognizes the c-series ganglioside–specific antigen A2B5.
A2B5 is predominantly expressed in embryonic and neonatal neural tissue. In the adult mammalian brain, A2B5 expression is restricted mainly to areas which retain neurogenic potential such as the subventricular zone (SVZ). Thus, A2B5 is considered as a marker for immature glial-committed precursors which are permanently generated in the SVZ. Glial precursor cells are defined as cells that give rise to glial cell types, such as astrocytes and oligodendrocytes.
Ganglioside GT3 and its O-acetylated derivative are the principal A2B5-reactive gangliosides7, and both antigens are down-regulated as the cells differentiate into mature oligodendrocytes. The Anti-A2B5 antibody can be used to monitor the maturation of oligodendrocyte progenitors.
原厂资料：
The clone 105HB29 recognizes the c-series ganglioside–specific antigen A2B5.
A2B5 is predominantly expressed in embryonic and neonatal neural tissue. In the adult mammalian brain, A2B5 expression is restricted mainly to areas which retain neurogenic potential such as the subventricular zone (SVZ). Thus, A2B5 is considered as a marker for immature glial-committed precursors which are permanently generated in the SVZ. Glial precursor cells are defined as cells that give rise to glial cell types, such as astrocytes and oligodendrocytes.
Ganglioside GT3 and its O-acetylated derivative are the principal A2B5-reactive gangliosides7, and both antigens are down-regulated as the cells differentiate into mature oligodendrocytes. The Anti-A2B5 antibody can be used to monitor the maturation of oligodendrocyte progenitors.
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