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RABBIT ANTI-VPS34 100 UG

 
包装:
运保温度: -20°C
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描述:

etails
Tested species reactivity Human , Mouse
Published species reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Synthetic peptide derived from the mid region of the human VPS34 protein.
Conjugate Unconjugated
Form Liquid
Concentration 0.25 mg/ml
Purification Antigen affinity chromatography
Storage buffer PBS, pH 7.4
Preservative 0.1% sodium azide
Storage Conditions -20°C
Tested Applications Dilution *
Flow Cytometry (Flow) 3-5 µg x 10^6 cells
Immunohistochemistry (Paraffin) (IHC (P)) 1:20
Immunoprecipitation (IP) Assay Dependent
Western Blot (WB) Assay Dependent

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

Published Applications  
Western Blot (WB) See 1 publications below

Background/Target Information

PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.

 


注意事项:

 
For Research Use Only. Not for use in diagnostic procedures. 
 
 


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