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MOUSE ANTI-ZO-1-FITC 100 UG

 
包装: 100 UG
运保温度: 4°C
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描述:

Details
Tested species reactivity Dog , Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Clone ZO1-1A12
Immunogen Human recombinant ZO-1 fusion protein encompassing amino acids 334-634
Conjugate FITC
Form Liquid
Concentration 0.5 mg/ml
Purification Affinity chromatography
Storage buffer PBS, pH 7.4, with 1% BSA, 50% glycerol
Preservative 0.1% sodium azide
Storage Conditions 4° C
Tested Applications Dilution *
ELISA (ELISA) 0.1-1.0 ug/ml
Immunocytochemistry (ICC) 1-10µg/mL
Immunofluorescence (IF) 1-10µg/mL
Western Blot (WB) 1-2 ug/ml

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

 

Background/Target Information

Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane- associated guanylate kinase (MAGUK) family and include occludin, ZO-1, ZO-2 and ZO-3. These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.

 


注意事项:

For Research Use Only. Not for use in diagnostic procedures. 
 


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